Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers

Autor(es)

Pernet Hara, Cristiane de Castro ; Franca, Eduardo Luzia ; Gomes Fagundes, Danny Laura ; de Queiroz, Adriele Ataides ; Cunha Rudge, Marilza Vieira ; Honorio-Franca, Adenilda Cristina ; Paranhos Calderon, Iracema de Mattos

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2016, p. 8-pg., 2016-01-01.

Resumo

The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16(+)CD56(-) NK cells increased, whereas that of CD16(+)CD56(+) decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16(+)CD56(-) and CD16(-)CD56(+). The placental extravillous layer of GDM and DM-2 showed an increase of CD16(+)CD56(-) cells and, irrespective of region, the proportion of CD16(-)CD56(+) cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-gamma higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-gamma and low levels of IL-1 beta and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-gamma. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-alpha, IL-17, and IFN-gamma. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16(+). (AU)

• Processo FAPESP: 13/13017-9 - Marcadores da imunomodulação no sangue materno e fetal e nas placentas de mães diabéticas ou com hiperglicemia gestacional leve
• Beneficiário: Iracema de Mattos Paranhos Calderon
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/24212-4 - Marcadores da imunomodulação no sangue materno e fetal e nas placentas de mães diabéticas ou com hiperglicemia gestacional leve
• Beneficiário: Cristiane de Castro Pernet Hara
• Modalidade de apoio: Bolsas no Brasil - Doutorado