The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease

Autor(es)

Rovai, E. S. ; Holzhausen, M.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2017, p. 13-pg., 2017-01-01.

Resumo

Proteinase-activated receptors 1 (PAR(1)) and 2 (PAR(2)) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial enzymes. PAR1 is expressed by the periodontal cells such as human gingival fibroblasts, gingival epithelial cells, periodontal ligament cells, osteoblasts, and monocytic cells and can be activated by thrombin, matrix metalloproteinase 1 (MMP-1), MMP-13, fibrin, and gingipains from Porphyromonas gingivalis. PAR2 is expressed by neutrophils, osteoblasts, oral epithelial cells, and human gingival fibroblasts, and its possible activators in the periodontium are gingipains, neutrophil proteinase 3, and mast cell tryptase. The mechanisms through which PARs can respond to periodontal enzymes and result in appropriate immune responses have until recently been poorly understood. This review discusses recent findings that are beginning to identify a cardinal role for PAR1 and PAR2 on periodontal tissue metabolism. (AU)

• Processo FAPESP: 15/07396-2 - Efeito da ativação do receptor ativado por protease do tipo 1 (PAR1) sobre a atividade osteogênica de células do ligamento periodontal
• Beneficiário: Marinella Holzhausen Caldeira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/11587-8 - Efeito da ativação do receptor ativado por protease do tipo 1 (par1) sobre a expressão de fatores osteogênicos de células do ligamento periodontal
• Beneficiário: Emanuel da Silva Rovai
• Modalidade de apoio: Bolsas no Brasil - Doutorado