Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients

Autor(es)

Bacci, Marcelo Rodrigues ; Aguiar Alves, Beatriz da Costa ; Cavallari, Marina Romera ; Azzalis, Ligia Ajaime ; de Rozier-Alves, Ross Martin ; Perez, Matheus Moreira ; Chehter, Ethel Zimberg ; Pereira, Edimar Cristiano ; Affonso Fonseca, Fernando Luiz

• Tipo de documento: Artigo Científico
• Fonte: Einstein (São Paulo); v. 15, n. 4, p. 4-pg., 2017-10-01.

Resumo

Objective: To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m(2). Methods: Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves. Results: Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point. Conclusion: These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level. (AU)

• Processo FAPESP: 14/04596-8 - Estudo de marcadores precoces de lesão renal em diabéticos tipo 2
• Beneficiário: Fernando Luiz Affonso Fonseca
• Modalidade de apoio: Auxílio à Pesquisa - Regular