Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair

Autor(es)

Silva, Jessica R. ; Burger, Beatriz ; Kuhl, Carolina M. C. ; Candreva, Thamiris ; dos Anjos, Mariah B. P. ; Rodrigues, Hosana G.

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2018, p. 17-pg., 2018-01-01.

Resumo

Wound healing is an evolutionarily conserved process that is essential for species survival. Wound healing involves a series of biochemical and cellular events that are tightly controlled, divided into 3 concomitant and overlapping phases: inflammation, proliferation, and remodelling. Poor wound healing or a chronic wound represents a silent epidemic that affects billions of people worldwide. Considering the involvement of immune cells in its resolution, recent studies are focused on investigating the roles of immune nutrients such as amino acids, minerals, and fatty acids on wound healing. Among the fatty acids, much attention has been given to omega-6 (omega-6) fatty acids since they can modulate cell migration and proliferation, phagocytic capacity, and production of inflammatory mediators. The present review summarizes current knowledge about the role of omega-6 fatty acids in the wound healing context. (AU)

• Processo FAPESP: 13/06810-4 - Mecanismos de ação dos ácidos graxos ômega-3 e ômega-6 no processo de reparo tecidual: enfoque neuro-imunológico
• Beneficiário: Hosana Gomes Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores