Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling

Autor(es)

Acevedo-Rodriguez, A. ; Kauffman, A. S. ; Cherrington, B. D. ; Borges, C. S. ; Roepke, T. A. ; Laconi, M.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroendocrinology; v. 30, n. 10, p. 11-pg., 2018-10-01.

Resumo

Reproduction and fertility are regulated via hormones of the hypothalamic-pituitary-gonadal (HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and pituitary, and allows for the promotion or inhibition of gonadal sex steroid secretion and function. In addition to guiding proper gonadal development and function, gonadal sex steroids also act in negative- and positive-feedback loops to regulate reproductive circuitry in the brain, including kisspeptin neurones, thereby modulating overall HPG axis status. Additional regulation is also provided by sex steroids made within the brain, including neuroprogestins. Furthermore, because reproduction and survival need to be coordinated and balanced, the HPG axis is able to modulate (and be modulated by) stress hormone signalling, including cortiscosterone, from the hypothalamic-pituitary-adrenal (HPA) axis. This review covers recent data related to the neural, hormonal and stress regulation of the HPG axis and emerging interactions between the HPG and HPA axes, focusing on actions at the level of the brain and pituitary. (AU)

• Processo FAPESP: 12/25350-1 - Efeitos da exposição in útero à betametasona sobre aspectos reprodutivos de ratos machos, com ênfase na qualidade espermática e fertilidade: uma abordagem multigeracional
• Beneficiário: Cibele dos Santos Borges
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/13660-1 - Efeitos da exposição in utero à betametasona sobre a instalação da puberdade e aspectos reprodutivos de ratas Wistar
• Beneficiário: Tainá Louise Pacheco
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica