| Texto completo | |
| Autor(es): |
Yamashita, Alex Shimura
;
das Neves, Rodrigo Xavier
;
Rosa-Neto, Jose Cesar
;
Lira, Fabio dos Santos
;
Batista, Miguel Luis, Jr.
;
Alcantara, Paulo Sergio
;
Otoch, Jose Pinhata
;
Seelaender, Marilia
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CYTOKINE; v. 89, p. 5-pg., 2017-01-01. |
| Resumo | |
Cachexia is associated with increased morbidity and mortality in cancer. The White adipose tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in cancer cachexia-related systemic inflammation. IFN-gamma is a pleiotropic cytokine that regulates several immune and metabolic functions. To assess whether IFN-gamma signalling in different WAT pads is modified along cancer-cachexia progression, we evaluated IFN-gamma receptors expression (IFNGR1 and IFNGR2) and IFN-gamma protein expression in a rodent model of cachexia (7, 10, and 14 days after tumour implantation). IFN-gamma protein expression was heterogeneously modulated in WAT, with increases in the mesenteric pad and decreased levels in the retroperitoneal depot along cachexia progression. Ifngr1 was up-regulated 7 days after tumour cell injection in mesenteric and epididymal WAT, but the retroperitoneal depot showed reduced Ifngr1 gene expression. Ifngr2 gene expression was increased 7 and 14 days after tumour inoculation in mesenteric WAT. The results provide evidence that changes in IFN-gamma expression and signalling may be perceived at stages preceding refractory cachexia, and therefore, might be employed as a means to assess the early stage of the syndrome. (C) 2016 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional |
| Beneficiário: | Marilia Cerqueira Leite Seelaender |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |