Effect of iontophoresis on fluoride uptake in enamel with artificial caries lesion

Autor(es)

Pauli, Maria Cibelle ; Machado, Cinthia Pereira ; Monteiro e Silva, Silas Arandas ; Bovi Ambrosano, Glaucia Maria ; Vianna Lopez, Renata Fonseca ; Leonardi, Gislaine Ricci

• Tipo de documento: Artigo Científico
• Fonte: BRAZILIAN ORAL RESEARCH; v. 33, p. 7-pg., 2019-01-01.

Resumo

Iontophoresis is a noninvasive technique, based on the application of a constant low-intensity electric current to facilitate the release of a variety of drugs, whether ionized or not, through biological membranes. The objective of this research was to evaluate the effect of iontophoresis using different electric current intensities on the uptake of fluoride in dental enamel with artificial caries lesions. In this in vitro operator-blind experiment, bovine enamel blocks (n = 10/group) with caries-like lesions and predetermined surface hardness were randomized into 6 groups: placebo gel without fluoride applied with a current of 0.8 mA (negative control), 2% NaF gel without application of any current, and 2% NaF gel applied with currents of 0.1, 0.2, 0.4 and 0.8 mA. Cathodic iontophoresis was applied for 4 min. The concentration of loosely bound fluoride (calcium fluoride) and firmly bound fluoride (fluorapatite) was determined. The results were analyzed by the nonparametric Kruskal-Wallis and Dunn tests. Iontophoresis at 0.8 mA, combined with the application of fluoridated gel (2% NaF), increased fluoride uptake in enamel with caries-like lesions, as either calcium fluoride or fluorapatite. (AU)

• Processo FAPESP: 11/04908-1 - Avaliação antioxidante dos compostos fenólicos naturais e aplicação em formulações de uso tópico para iontoforese in vitro
• Beneficiário: Gislaine Ricci Leonardi
• Modalidade de apoio: Auxílio à Pesquisa - Regular