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Peptide Design Principles for Antimicrobial Applications

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Autor(es):
Torres, Marcelo D. T. ; Sothiselvam, Shanmugapriya ; Lu, Timothy K. ; de la Fuente-Nunez, Cesar
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Molecular Biology; v. 431, n. 18, p. 21-pg., 2019-08-23.
Resumo

The increased incidence of bacterial resistance to available antibiotics represents a major global health problem and highlights the need for novel anti-infective therapies. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics. AMPs are versatile, have almost unlimited sequence space, and can be tuned for broad-spectrum or specific activity against microorganisms. However, several obstacles remain to be overcome in order to develop AMPs for medical use, such as toxicity, stability, and bacterial resistance. We lack standard experimental procedures for quantifying AMP activity and do not yet have a clear picture of the mechanisms of action of AMPs. The rational design of AMPs can help solve these issues and enable their use as new antimicrobials. Here we provide an overview of the main physicochemical features that can be engineered to achieve enhanced bioactivity and describe current strategies being used to design AMPs. (C) 2018 Published by Elsevier Ltd. (AU)

Processo FAPESP: 14/04507-5 - Aplicações biológicas de novos peptídeos antimicrobianos
Beneficiário:Marcelo Der Torossian Torres
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/24413-0 - Peptídeos anfipáticos catiônicos antimicrobianos e antibiofilmes
Beneficiário:Marcelo Der Torossian Torres
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado