Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid

Autor(es)

de Almeida, Amanda Cosmo ; Ferreira, Patricia Osorio ; Torquetti, Carolina ; Ekawa, Bruno ; Sobral Carvalho, Ana Carina ; dos Santos, Everton Carvalho ; Caires, Flavio Junior

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 140, n. 5, p. 11-pg., 2019-11-06.

Resumo

Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams. (AU)

• Processo FAPESP: 17/14936-9 - Preparação, caracterização e estudos termoanalíticos de catalisadores heterogêneos de selenatos duplos de Mg/Co e Mg/Cu na produção de biodiesel a partir de diferentes óleos
• Beneficiário: Massao Ionashiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/09022-7 - Estudos termoanalíticos, síntese e caracterização dos co-cristais sólidos de alguns antibióticos (fluoroquinolonas) com alguns co-formadores
• Beneficiário: Massao Ionashiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/24378-6 - Síntese, caracterização e estudo termoanalítico de cocristais de Valsartana, Candesartana Cilexetila e Olmesartana medoxomila
• Beneficiário: Flávio Junior Caires
• Modalidade de apoio: Auxílio à Pesquisa - Regular