Role of spinal neurons in the maintenance of elevated sympathetic activity: a novel therapeutic target?

Autor(es)

Milanez, Maycon I. O. ; Nishi, Erika E. ; Bergamaschi, Cassia T. ; Campos, Ruy R.

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 319, n. 3, p. 6-pg., 2020-09-01.

Resumo

The control of sympathetic vasomotor activity involves a complex network within the brain and spinal circuits. An extensive range of studies has indicated that sympathoexcitation is a common feature in several cardiovascular diseases and that strategies to reduce sympathetic vasomotor overactivity in such conditions can be beneficial. In the present mini-review, we present evidence supporting the spinal cord as a potential therapeutic target to mitigate sympathetic vasomotor overactivity in cardiovascular diseases, focusing mainly on the actions of spinal angiotensin II on the control of sympathetic preganglionic neuronal activity. (AU)

• Processo FAPESP: 18/02671-3 - Ações funcionais e moleculares do nervo renal na doença renal crônica experimental
• Beneficiário: Cassia Marta de Toledo Bergamaschi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/01898-4 - Avaliação das projeções encéfalo-espinais no estabelecimento temporal da hiperativação simpática renal na Hipertensão Renovascular
• Beneficiário: Maycon Igor de Oliveira Milanez
• Modalidade de apoio: Bolsas no Brasil - Doutorado