Preparation of Scaffolds of Amorphous Calcium Phosphate and Bacterial Cellulose for Use in Tissue Regeneration by Freeze-Drying Process

Autor(es)

Tiomnova, Olinka Tiomno ; Coelho, Fernanda ; Garcia Pellizaro, Thales A. ; Rodriguez Chanfrau, Jorge Enrique ; de Oliveira Capote, Ticiana Sidorenko ; Basmaji, Pierre ; Pantoja, Yaymarilis Veranes ; Guastaldi, Antonio Carlos

• Tipo de documento: Artigo Científico
• Fonte: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY; v. 11, n. 1, p. 11-pg., 2021-02-15.

Resumo

The elaboration of scaffolds for use in tissue regeneration processes plays an important role in the area of biomaterials. Natural and synthetic polymers. together with calcium phosphates. form suitable compounds for these studies because their combinations favor the union of the properties of both materials. such as their biocompatibility, biofunctionality. shape, porosity. and mechanical properties. The objective of this work as to do clop a scaffold of amorphous calcium phosphate and bacterial cellulose, applying a freeze-drying process. The results demonstrated the feasibility of scaffolds elaboration applying the freeze-drying methodology. The formulation that presented the best results was the one that contained amorphous calcium phosphate (50%), bacterial cellulose gel (20%). and sodium alginate (30%). Cytotoxicity studies showed that the studied formulation did not present cytotoxicity, promoting cell viability. (C) 2020 by the authors. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). (AU)

• Processo FAPESP: 17/15487-3 - Desenvolvimento de tintas (inks) de polímeros/fosfatos de cálcio empregando-se impressão 3D para obtenção de scaffolds aplicados à engenharia de tecidos
• Beneficiário: Jorge Enrique Rodriguez Chanfrau
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE