Systemic Cytokine Profiles of CD4+T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD

Autor(es)

Uzeloto, Juliana Souza ; de Toledo-Arruda, Alessandra Choqueta ; de Alencar Silva, Bruna Spolador ; Golim, Marjorie de Assis ; Marques Braz, Aline Marcia ; de Lima, Fabiano Francisco ; Grigoletto, Isis ; Cipulo Ramos, Ercy Mara

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE; v. 15, p. 10-pg., 2020-01-01.

Resumo

Aims: To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients. Patients and Methods: Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-alpha) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed. Results: Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-alpha in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day. Conclusion: Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD. (AU)

• Processo FAPESP: 18/04870-3 - Investigação do efeito do treinamento físico combinado no perfil inflamatório e capacidade funcional de pacientes com dpoc: estudo clínico randomizado
• Beneficiário: Juliana Souza Uzeloto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/10145-7 - Efeitos da inserção de um circuito funcional ao treinamento aeróbico e resistido na funcionalidade, atividade física na vida diária e resposta imuno metabólica de Pacientes com DPOC: um estudo clínico randomizado com follow up
• Beneficiário: Ercy Mara Cipulo Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular