Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats

Autor(es)

Vitória Ricardo ^[1] ; Luiz Gustavo de Sousa ^[2] ; Isabela Hallak Regalo ^[3] ; Dimitrius Leonardo Pitol ^[4] ; Karina Fittipaldi Bombonato-Prado ^[5] ; Simone Cecilio Hallak Regalo ^[6] ; Selma Siessere ^[7]

Afiliação do(s) autor(es)

^[1] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[2] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[3] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[4] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[5] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[6] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

^[7] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Basic and Oral Biology - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 34, n. 3, p. 50-56, 2023-07-17.

Resumo

Abstract Osteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit osteoclastogenesis. The purpose of this investigation was to analyze the influence of lycopene in the bone neoformation of calvaria defects in ovariectomized rats utilizing the concentration of 45 mg/kg. Wistar Hannover female rats were divided into ovariectomized and sham groups. The ovariectomized animals received 45 mg/kg lycopene (OvxL) or water (Ovx) by daily gavage the day after ovariectomy/sham surgery for 16 weeks. Twelve weeks after ovariectomy, there were performed 5-mm calvaria defects followed by euthanasia after 4 weeks. Samples of bone tissue were collected to perform morphological and morphometrical analysis of the neoformed bone area, and percentage with Software Image J. Morphological evaluation showed mature bone with more osteocytes in the group OVxL when compared to the other groups. The morphometrical analysis demonstrated a significant increase of bone neoformation in the group OvxL (p<0.05). The data obtained suggest that lycopene benefits bone repair in the absence of estrogenic hormones. (AU)

• Processo FAPESP: 17/20407-9 - Efeito da administração sistêmica do licopeno no reparo ósseo em calvária de ratas ovariectomizadas
• Beneficiário: Vitória Ricardo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica