Ancestry and self-reported race in Brazilian breast cancer women

Autor(es)

René Aloisio da Costa Vieira ; Débora Sant'Anna ^[2] ; Ana Carolina Laus ^[3] ; Rui Manuel Reis

• Tipo de documento: Artigo Científico
• Fonte: Revista da Associação Médica Brasileira; v. 69, n. 12 2023-10-30.

Resumo

SUMMARY OBJECTIVE: This study aimed to evaluate the association between self-reported race/color and ancestry in Brazilian patients with breast cancer. METHODS: This was an observational, transversal, epidemiological study, evaluating race and ancestry in 1,127 patients with breast cancer. For genetic ancestry, a 46-AIM-INDEL panel was used. The ancestral profile was evaluated with the Structure v.2.3.3 software. Descriptive statistics were performed. To assess differences between race and ancestry, an analysis of variance with Bonferoni adjustment was used. RESULTS: The race distribution was 77.7% white, 17.6% brown, 4.1% black, 0.4% yellow, and 0.3% cafuse. The African ancestry proportion was significantly (p<0.001) more evident in black [0.63±0.21 (0.17–0.96)], followed by brown [0.25±0.16 (0.02–0.70)], and less frequent in white skin color. The European ancestry proportion was significantly (p<0.001) higher in white [0.72±0.17 (0.02–0.97)], followed by brown [0.57±0.19 (0.12–0.92)], yellow [0.27±0.31 (0.12–0.620], and black [0.24±0.19 (0.02–0.72)]. The Asiatic ancestry proportion is significantly (p<0.001) higher in yellow [0.48±0.51 (0.04–0.93)]. The Amerindian ancestry proportion frequency was the least frequent in all groups, and cafuse patients did not express differences between all race groups. The brown race group presented differences in African and European ancestry. CONCLUSION: Although we found many similarities between white European ancestry, black African ancestry, and yellow Asian ancestry, there is great miscegenation between patients. Although they can be labeled as having one race, they do present many ancestral genes that would allow their inclusion in another race group. (AU)

• Processo FAPESP: 17/26304-7 - Caracterização da ancestralidade em pacientes portadoras de câncer de mama no Brasil e sua correlação com o subtipo molecular e localização geográfica de origem.
• Beneficiário: René Aloisio da Costa Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/16629-9 - Caracterização da ancestralidade em pacientes portadoras de câncer de mama no Brasil e sua correlação com o subtipo molecular e localização geográfica de origem
• Beneficiário: Débora Sant' Anna de Andrade e Silva
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico