Autor(es)

Neto, Jose Arimatea de Oliveira Nery ; Yariwake, Victor Yuji ; Camara, Niels Olsen Saraiva ; Andrade-Oliveira, Vinicius

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHARMACOLOGY; v. 14, p. 20-pg., 2023-10-19.

Resumo

Recent studies suggest that disruptions in intestinal homeostasis, such as changes in gut microbiota composition, infection, and inflammatory-related gut diseases, can be associated with kidney diseases. For instance, genomic investigations highlight how susceptibility genes linked to IgA nephropathy are also correlated with the risk of inflammatory bowel disease. Conversely, investigations demonstrate that the use of short-chain fatty acids, produced through fermentation by intestinal bacteria, protects kidney function in models of acute and chronic kidney diseases. Thus, the dialogue between the gut and kidney seems to be crucial in maintaining their proper function, although the factors governing this crosstalk are still emerging as the field evolves. In recent years, a series of studies have highlighted the significance of enteroendocrine cells (EECs) which are part of the secretory lineage of the gut epithelial cells, as important components in gut-kidney crosstalk. EECs are distributed throughout the epithelial layer and release more than 20 hormones in response to microenvironment stimuli. Interestingly, some of these hormones and/or their pathways such as Glucagon-Like Peptide 1 (GLP-1), GLP-2, gastrin, and somatostatin have been shown to exert renoprotective effects. Therefore, the present review explores the role of EECs and their hormones as regulators of gut-kidney crosstalk and their potential impact on kidney diseases. This comprehensive exploration underscores the substantial contribution of EEC hormones in mediating gut-kidney communication and their promising potential for the treatment of kidney diseases. (AU)

• Processo FAPESP: 21/03913-3 - Influência da obesidade nos mecanismos de tolerância periférica e na modulação da resposta imune no intestino delgado de camundongos
• Beneficiário: Victor Yuji Yariwake
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/14755-0 - Modulação da microbiota intestinal e do sistema imune pelas células epiteliais intestinais: da homeostase tecidual às doenças
• Beneficiário: Vinicius de Andrade Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 22/08362-8 - Biologia das células enteroendócrinas na homoestasiae durante a inflamação intestinal
• Beneficiário: José Arimatéa Oliveira Nery Neto
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto