| Texto completo | |
| Autor(es): |
Nobrega, Guilherme M.
;
Jones, Brittany R.
;
Mysorekar, Indira U.
;
Costa, Maria Laura
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | American Journal of Reproductive Immunology; v. 92, n. 2, p. 13-pg., 2024-08-01. |
| Resumo | |
The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to the global COVID-19 pandemic, significantly impacting the health of pregnant women. Obstetric populations, already vulnerable, face increased morbidity and mortality related to COVID-19, aggravated by preexisting comorbidities. Recent studies have shed light on the potential correlation between COVID-19 and preeclampsia (PE), a leading cause of maternal and perinatal morbidity worldwide, emphasizing the significance of exploring the relationship between these two conditions. Here, we review the pathophysiological similarities that PE shares with COVID-19, with a particular focus on severe COVID-19 cases and in PE-like syndrome cases related with SARS-CoV-2 infection. We highlight cellular and molecular mechanistic inter-connectivity between these two conditions, for example, regulation of renin-angiotensin system, tight junction and barrier integrity, and the complement system. Finally, we discuss how COVID-19 pandemic dynamics, including the emergence of variants and vaccination efforts, has shaped the clinical scenario and influenced the severity and management of both COVID-19 and PE. Continued research on the mechanisms of SARS-CoV-2 infection during pregnancy and the potential risk of developing PE from previous infections is warranted to delineate the complexities of COVID-19 and PE interactions and to improve clinical management of both conditions. (AU) | |
| Processo FAPESP: | 21/09937-1 - COVID-19 e pré-eclâmpsia: causa ou consequência? |
| Beneficiário: | Maria Laura Costa do Nascimento |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |