Nanotechnology strategies to address challenges in topical and cellular delivery of siRNAs in skin disease therapy

Autor(es)

Silvestrini, Ana Vitoria Pupo ; Morais, Milena Finazzi ; Debiasi, Bryan Wender ; Praca, Fabiola Garcia ; Bentley, Maria Vitoria Lopes Badra

• Tipo de documento: Artigo Científico
• Fonte: Advanced Drug Delivery Reviews; v. 207, p. 32-pg., 2024-02-14.

Resumo

Gene therapy is one of the most advanced therapies in current medicine. In particular, interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in recent years as it is a highly versatile, selective and specific therapy. In dermatological conditions, topical delivery of siRNA offers numerous therapeutic advantages, mainly by inhibiting the expression of target transcripts directly in the skin. However, crossing the stratum corneum and overcoming intracellular barriers is an inherent challenge. Substantial efforts by scientists have moved towards the use of multimodal and multifunctional nanoparticles to overcome these barriers and achieve greater bioavailability in their site of action, the cytoplasm. In this review the most innovative strategies based on nanoparticle and physical methods are presented, as well as the design principles and the main factors that contribute to the performance of these systems. This review also highlights the synergistic contributions of medicine, nanotechnology, and molecular biology to advancing translational research into siRNA-based therapeutics for skin diseases. (AU)

• Processo FAPESP: 22/01969-4 - Nanopartículas líquido-cristalinas multifuncionais para co-liberação de siRNAs e piperina no tratamento tópico do vitiligo: desenvolvimento, caracterização e estudos in vitro
• Beneficiário: Ana Vitória Pupo Silvestrini
• Modalidade de apoio: Bolsas no Brasil - Doutorado