| Texto completo | |
| Autor(es): Mostrar menos - |
Morais, Lucas Vinicius
;
dos Santos, Samuel Nascimento
;
Gomes, Tabatah Hellen
;
Malta Romano, Camila
;
Colombo-Souza, Patricia
;
Amaral, Jonatas Bussador
;
Shio, Marina Tiemi
;
Neves, Lucas Melo
;
Bachi, Andre Luis Lacerda
;
Franca, Carolina Nunes
;
Nali, Luiz Henrique da Silva
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 19, n. 5, p. 17-pg., 2024-05-16. |
| Resumo | |
Background Human Endogenous Retroviruses (HERVs) are fossil viruses that composes 8% of the human genome and plays several important roles in human physiology, including muscle repair/myogenesis. It is believed that inflammation may also regulate HERV expression, and therefore may contribute in the muscle repair, especially after training exercise. Hence, this study aimed to assess the level of HERVs expression and inflammation profile in practitioners' resistance exercises after an acute strength training session. Methods Healthy volunteers were separated in regular practitioners of resistance exercise training group (REG, n = 27) and non-trained individuals (Control Group, n = 20). All individuals performed a strength exercise section. Blood samples were collected before the exercise (T0) and 45 minutes after the training session (T1). HERV-K (HML1-10) and W were relatively quantified, cytokine concentration and circulating microparticles were assessed. Results REG presented higher level of HERV-W expression (similar to 2.5 fold change) than CG at T1 (p<0.01). No difference was observed in the levels of HERV-K expression between the groups as well as the time points. Higher serum TNF-alpha and IL-10 levels were verified post-training session in REG and CG (p<0.01), and in REG was found a positive correlation between the levels of TNF-alpha at T1 and IL-10 at T0 (p = 0.01). Finally, a lower endothelial microparticle percentage was observed in REG at T1 than in T0 (p = 0.04). Conclusion REG individuals exhibited a significant upregulation of HERV-W and modulation of inflammatory markers when compared to CG. This combined effect could potentially support the process of skeletal muscle repair in the exercised individuals. (AU) | |
| Processo FAPESP: | 23/08773-0 - Expressão de retrovírus endógenos humanos em condições de saúde e doença: possível papel mediador de condições inflamatórias e imunopatogênicas |
| Beneficiário: | Luiz Henrique da Silva Nali |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/11619-5 - Investigação da expressão de retrovírus endógenos humanos K e W em praticantes de exercícios físicos |
| Beneficiário: | Lucas Vinícius Morais |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |