Comprehensive mapping of SARS-CoV-2 inhibition using essential or vegetable oils

Autor(es)

Souza, Alana G. ; Yudice, Eliana Della Coletta ; Campos, Ivana Barros de ; Ferreira, Rafaela R. ; Ferreira, Greiciele S. ; Dal Col, Rute ; Rosa, Derval dos S.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR LIQUIDS; v. 387, p. 7-pg., 2023-07-19.

Resumo

Introduction: The new SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has spread exponentially since the first recognition of the new virus and continues to infect millions of individuals worldwide. The importance of contaminated surfaces in transmission is uncertain. Minimizing surface contact, hand hygiene after surface contact, and cleaning and disinfecting the environment are recommended to reduce the risk of acquiring SARS-CoV-2. As surfaces are prone to transmitting COVID-19 infection, highly exposed surface areas need to be cleaned frequently with a suitable disinfectant. Essential oils have been extensively used as antimi-crobial extract for several microorganisms. However, no experimental studies have previously investigated these compounds against the SARS-CoV-2.Objectives: In this work, we conducted a comprehensive mapping of SARS-CoV-2 protein denaturation using different essential oils (EO) aiming at the future development of natural disinfectants.Methods: The tested oils were melaleuca, cinnamon, cardamom, buriti, and linalool. Positive nasopharyngeal samples of COVID-19 patients were exposed in direct contact with EOs, at different times, and the virus elimi-nation efficiency was verified through an immunochromatographic Rapid Antigen Test.Results: The best EOs were Melaleuca alternifolia and Cinnamomum cassia, which denatured SARS-CoV-2 proteins at least with 5 min of contact by interfering with the viral envelope or the spike protein. Cardamom oil probably damaged the virus capsid, and buriti oil disrupted the viral protein envelop. Linalool oil did not denature SARS-CoV-2 proteins.Conclusions: Oils have a considerable potential to produce ecologically friendly disinfectants that can inactivate SARS-CoV-2 in different contact times depending on the mechanism of action and oil-active compounds. (AU)

• Processo FAPESP: 20/13703-3 - Materiais porosos ecológicos para a recuperação e reavaliação de metais recuperados de água contaminada
• Beneficiário: Derval dos Santos Rosa
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/11277-7 - Filmes de PBAT com nanoestruturas de celulose tratadas com óleos essenciais encapsulados para embalagens ativas
• Beneficiário: Derval dos Santos Rosa
• Modalidade de apoio: Auxílio à Pesquisa - Regular