| Texto completo | |
| Autor(es): Mostrar menos - |
Oliveira, Inaeh de Paula
;
Oliveira, Victoria Regina da Silva
;
Alonso-Matielo, Heloisa
;
Magalhaes, Beatriz
;
de Andrade, Daniel Ciampi
;
Teixeira, Manoel Jacobsen
;
Calsaverini, Milena Cristina Dias
;
Ribeiro, Fernando de Quadros
;
Araujo, Jose Deney Alves
;
Nakaya, Helder Takashi Imoto
;
Otoch, Jose Pinhata
;
Dale, Camila Squarzoni
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PAIN PRACTICE; v. 24, n. 5, p. 15-pg., 2024-02-13. |
| Resumo | |
BackgroudDiabetic neuropathy (DN) is one of the most common complications of diabetes, affecting about half of individuals with the disease. Among the various symptoms of DN, the development of chronic pain stands out and manifests as exacerbated responses to sensorial stimuli. The conventional clinical treatments used for general neuropathy and associated painful symptoms, still brings uncomplete and unsatisfactory pain relief. Patients with neuropathic pain syndromes are heterogeneous. They present with a variety of sensory symptoms and pain qualities which difficult the correct diagnosis of sensory comorbidities and consequently, the appropriate chronic pain management.AimsHerein, we aimed to demonstrate the existence of different sensory profiles on diabetic patients by investigating epidemiological and clinical data on the symptomatology of a group of patients with DN.MethodsThis is a longitudinal and observational study, with a sample of 57 volunteers diagnosed with diabetes from outpatient day clinic of Hospital Universitario of the University of Sao Paulo-Brazil. After being invited and signed the Informed Consent Form (ICF), patients were submitted to clinical evaluation and filled out pain and quality of life questionnaires. They also performed quantitative sensory test (QST) and underwent skin biopsy for correlation with cutaneous neuropathology.ResultsData demonstrate that 70% of the studied sample presented some type of pain, manifesting in a neuropathic or nociceptive way, what has a negative impact on the life of patients with DM. We also demonstrated a positive association between pain and anxiety and depression, in addition to pain catastrophic thoughts. Three distinct profiles were identified in the sample, separated according to the symptoms of pain: (i) subjects without pain; (ii) with mild or moderate pain; (iii) subjects with severe pain. We also identified through skin biopsy that diabetic patients presented advanced sensory impairment, as a consequence of the degeneration of the myelinated and unmyelinated peripheral fibers. This study characterized the painful symptoms and exteroceptive sensation profile in these diabetic patients, associated to a considerable level of sensory degeneration, indicating, and reinforcing the importance of the long-term clinical monitoring of individuals diagnosed with DM, regarding their symptom profiles and exteroceptive sensitivity. (AU) | |
| Processo FAPESP: | 16/10372-0 - Estudo dos mecanismos moleculares envolvidos na analgesia induzida por tratamento com laser de baixa intensidade na neuropatia periférica diabética experimental |
| Beneficiário: | Victória Regina da Silva Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 18/14560-1 - "Prevalência de dor neuropática em pacientes diabéticos, validação de instrumentos de rastreio da dor, correlação com neuropatologia cutânea polimorfismos para TNF alfa, perfil de cicatrização tecidual e efeito da terapia com fotobiomodulação" |
| Beneficiário: | Camila Squarzoni Dale |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/18483-1 - Fotobiomodulação como terapia complementar no tratamento de feridas diabéticas: efeitos sobre a sensibilidade dolorosa exteroceptiva, processo de cicatrização e possíveis mecanismos moleculares |
| Beneficiário: | Victória Regina da Silva Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |