Tailored alginate sponges loaded with x-carrageenan beads for controlled release of curcumin

Autor(es)

dos Santos, Erica Mendes ; Gaspar, Rita Caiado ; De Ceulaer, Femke ; Chiu, Hao-Chun ; De Wever, Pieter ; Mazzola, Priscila Gava ; Fardim, Pedro

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 280, p. 9-pg., 2024-09-23.

Resumo

This study presents an innovative approach to develop and characterize an alginate sponge containing x-carrageenan (x-CRG) beads loaded with curcumin. The beads were fabricated using varying concentrations of x-CRG, and their properties were extensively evaluated using inverted phase-contrast microscopy, Scanning Electron Microscopy (SEM), FTIR, swelling behavior, mass distribution, encapsulation efficiency, in vitro drug release and kinetics of drug release. Beads formulated with specific concentrations of x-CRG that exhibited optimal performance were then integrated into an alginate sponge matrix, which underwent similar comprehensive testing procedures as the individual beads. The characterized beads displayed a spherical morphology, a notable swelling degree of approximately 146 %, excellent mass uniformity, encapsulation efficiencies higher than 90 % and drug release rate exceeding 70 %. Moreover, the alginate sponge formulation demonstrated a satisfactory drug release profile of 67.9 +/- 0.6 %. In terms of drug release kinetics, the Higuchi model was the most effective in explaining the release of curcumin from beads and sponge. These findings underscore the potential of both the beads and the sponge as effective vehicles for the controlled delivery of curcumin, positioning them as promising candidates for pharmaceutical applications across various fields. (AU)

• Processo FAPESP: 21/14698-6 - Desenvolvimento de esponjas contendo microesferas de polissacarídeos carregadas com curcumina
• Beneficiário: Érica Mendes dos Santos
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 24/02159-1 - Ultra-mesh: aprimorando opções de tratamento utilizando aplicação refinada de membranas, extratos e sacarídeos para cicatrização
• Beneficiário: Priscila Gava Mazzola
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 22/06228-2 - Desenvolvimento de membrana polissacarídica contendo extrato de plantas para o tratamento de Úlcera por pressão
• Beneficiário: Priscila Gava Mazzola
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/11333-4 - Desenvolvimento de membrana polissacarídica contendo extrato da casca de Spondias mombin L. para o tratamento de Úlcera por Pressão
• Beneficiário: Érica Mendes dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado