Methods for extraction, isolation and sequencing of cyclotides and others cyclic peptides with anti-helminthic activities: An overview

Autor(es)

Eteme, Olivier Ndogo ; Zondegoumba, Ernestine Nkwengoua ; Tadayozzi, Yasmin Saegusa ; Serafim, Jessica Aparecida ; Leite, Wendell Queiroz ; Severino, Mariane de Freitas Genari ; Vicente, Eduardo Festozo

• Tipo de documento: Artigo Científico
• Fonte: Parasitology International; v. 98, p. 10-pg., 2023-10-04.

Resumo

The mortality rate caused by parasitic worms on their hosts is of great concern and studies have been carried out to find molecules to reduce the prevalence, host-parasite interaction, and resistance of parasites to treatments. Existing drugs on the market are very often toxic and have many side effects, hence the need to find new, more active molecules. It has been demonstrated in several works that medicinal plants constitute a wide range of new molecules that can solve this problem. Several works have already been able to demonstrate that cyclic peptides of plant origin have shown good activity in the fight against different types of helminths. Therefore, this review aims to provide a general overview of the methods and techniques of extraction, isolation, activities and mechanisms of action of cyclotides and other cyclic peptides for application in the treatment of helminthic infections. (AU)

• Processo FAPESP: 21/06706-9 - Peptídeos antimicrobianos: expandindo horizontes para otimização da performance na produção animal
• Beneficiário: Eduardo Festozo Vicente
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 22/02808-4 - Avaliação de propriedades inibitórias de proteases e atividades biológicas de ciclotídeos de Allexis cauliflora para aplicação em nutrição animal
• Beneficiário: Ndogo Eteme Olivier
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado