| Texto completo | |
| Autor(es): |
Calazans, Ana Paula Carvalho Thiers
;
Milani, Thamires Melchiades Silva
;
Prata, Ana Silvia
;
Clerici, Maria Teresa Pedrosa Silva
;
Nicoli, Jacques Robert
;
Martins, Flaviano Santos
;
Borges, Marcos Carvalho
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CURRENT DEVELOPMENTS IN NUTRITION; v. 8, n. 4, p. 9-pg., 2024-04-14. |
| Resumo | |
Background: The administration of probiotics has been shown to be bene fi cial in asthma. The administration of Saccharomyces cerevisiae UFMG A-905 prevented asthma development. Traditionally, probiotics are administered using dairy -based matrices, but other vehicles (e.g., fruit juices, biscuits, candies, and breads) can be used. Objectives: This study aimed to assess the effect of bread fermented with S. cerevisiae UFMG A-905 in asthma prevention. Methods: Three breads were produced: fermented with commercial yeast, fermented with S. cerevisiae UFMG A-905, and fermented with S. cerevisiae UFMG A-905 with the addition of alginate microcapsules containing live S. cerevisiae UFMG A-905. Characterization of the microbial composition of the breads was performed. Male Balb/c mice were sensitized and challenged with ovalbumin. Breads were administered 10 d before the fi rst sensitization and during sensitization and challenge protocol. Yeast fecal count, in vivo airway hyperresponsiveness, and airway and lung in fl ammation were assessed. Results: In UFMG A-905 bread, there was an increase in yeast number and a decrease in total and lactic acid bacteria. Animals that received S. cerevisiae UFMG A-905 fermented bread with microcapsules had a signi fi cant increase in yeast recovery from feces. S. cerevisiae UFMG A-905 - fermented breads partially reduced airway in fl ammation, decreasing eosinophils and IL5 and IL13 concentrations. When adding microcapsules, the bread also diminished airway hyperresponsiveness and increased IL17A concentrations. Conclusions: S. cerevisiae UFMG A-905 was able to generate long -fermentation breads. Microcapsules were a safe and viable way to inoculate the live yeast into food. The administration of breads fermented with S. cerevisiae UFMG A-905 prevented asthma -like characteristics, being more pronounced when the breads contained microcapsules with live yeast. (AU) | |
| Processo FAPESP: | 10/20600-4 - Estudo da prevenção e tratamento da asma induzida por alérgeno em um modelo animal com a administração de Saccharomyces cerevisiae vivas e inativadas pelo calor |
| Beneficiário: | Marcos de Carvalho Borges |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |