| Texto completo | |
| Autor(es): |
Benites, Nikollas M.
;
Rodrigues, Beatriz
;
da Silveira, Carlos H.
;
Kushmerick, Christopher
;
Leao, Ricardo M.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Neurophysiology; v. 130, n. 1, p. 18-pg., 2023-07-01. |
| Resumo | |
The dorsal cochlear nucleus (DCN) in the auditory brainstem integrates auditory and somatosensory information. Mature DCN fusiform neurons fall into two qualitatively distinct types: quiet, with no spontaneous regular action potential firing, or active, with regular spontaneous action potential firing. However, how these firing states and other electrophysiological properties of fusi-form neurons develop during early postnatal days to adulthood is not known. Thus, we recorded fusiform neurons from mice from P4 to P21 and analyzed their electrophysiological properties. In the prehearing phase (P4-P13), we found that most fusiform neurons are quiet, with active neurons emerging after hearing onset at P14. Subthreshold properties underwent significant changes before hearing onset, whereas changes to the action potential waveform occurred mainly after P14, with the depolarization and repolarization phases becoming markedly faster and half-width significantly decreased. The activity threshold in post-hearing neurons was more negative than in prehearing cells. Persistent sodium current (I-NaP) was increased after P14, coinciding with the emergence of spontaneous firing. Thus, we suggest that posthearing expression of INaP leads to hyperpolarization of the activity threshold and the active state of the fusiform neuron. At the same time, other changes refine the passive membrane properties and increase the speed of action potential firing of fusiform neurons. (AU) | |
| Processo FAPESP: | 19/13458-1 - Alterações durante o desenvolvimento das correntes iônicas e neurotransmissão de neurônios ligados a processamento auditivo: efeitos do ambiente acústico |
| Beneficiário: | Ricardo Mauricio Xavier Leão |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |