Mast Cells and Ethanol Consumption: Interactions in the Prostate, Epididymis and Testis of UChB Rats

Autor(es):Mostrar menos -

Mendes, Leonardo O. ^{[1, 2]} ; Amorim, Joao Paulo A. ^{[1, 2]} ; Teixeira, Giovana R. ^[1] ; Chuffa, Luiz Gustavo A. ^{[1, 2]} ; Fioruci, Beatriz Aparecida ^{[1, 2]} ; Pimentel, Tatiana Aparecida ^[3] ; de Mello, Jr., Wilson ^[1] ; Padovani, Carlos Roberto ^[4] ; Pereira, Sergio ^[1] ; Martinez, Marcelo ^[5] ; Pinheiro, Patricia Fernanda F. ^[1] ; Oliani, Sonia Maria ^[3] ; Martinez, Francisco Eduardo ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Dept Anat, Inst Biosci, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Estadual Campinas UNICAMP, Inst Biol, Cellular & Struct Biol Program, Campinas, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Inst Biosci Humanities & Exact Sci, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil

^[4] UNESP Univ Estadual Paulista, Inst Biosci, Dept Biostat, Botucatu, SP - Brazil

^[5] Univ Fed Sao Carlos, Dept Morphol & Pathol, BR-13560 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Reproductive Immunology; v. 66, n. 3, p. 170-178, SEP 2011.
• Citações Web of Science: 10

Resumo

Problem Alcoholism has reached alarming proportions while fertility rates slowing in populations. The assessment of inflammatory effects with emphasis on the variation of the mast cells comparing ethanol chronic ingestion on reproductive organs deserves attention. Method of study The mast cells were investigated with light microscopy using toluidine blue to locate and count total mast cells and immunohistochemistry to identify the connective tissue mast cells (CTMC). Results The increase in total mast cells in the prostate, total and degranulated mast cells in epididymis of UChB rats was accompanied by a greater proportion of mucosal mast cells (MMC) in these organs. In addition, a lower incidence of degranulated mast cells was observed in epididymis of control rats. Conclusions Ethanol increases the number of total and degranulated mast cells in the prostate and epididymis, as well as associated with increasing MMC, and therefore, it could be leading to inflammation in these organs. (AU)

• Processo FAPESP: 08/52722-1 - Mastócitos no lobo ventral da próstata, no epidídimo, testículo de ratos UChB (bebedores voluntários de etanol a 10%)
• Beneficiário: Leonardo de Oliveira Mendes
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/57222-7 - Mastócitos no lobo ventral da próstata, no epidídimo e no testículo de ratos UChB (bebedores voluntários de etanol a 10%)
• Beneficiário: Francisco Eduardo Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Regular