Impaired Humoral Response to Vaccines among HIV-Exposed Uninfected Infants

Autor(es)

Abramczuk, Beatriz Mariana ^[1] ; Mazzola, Tais Nitsch ^[1] ; Franco Moreno, Yara Maria ^[1] ; Zorzeto, Tatiane Queiroz ^[1] ; Quintilio, Wagner ^[2] ; Wolf, Paulo Silva ^[2] ; Blotta, Maria Heloisa ^[3] ; Morcillo, Andre Moreno ^[1] ; Nolasco da Silva, Marcos Tadeu ^[1] ; dos Santos Vilela, Maria Marluce ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas Med Sch, Ctr Invest Pediat, Dept Pediat, BR-35218972 Sao Paulo - Brazil

^[2] Butantan Inst, Sao Paulo - Brazil

^[3] State Univ Campinas Med Sch, Dept Clin Pathol, BR-35218972 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical and Vaccine Immunology; v. 18, n. 9, p. 1406-1409, SEP 2011.
• Citações Web of Science: 37

Resumo

Little is known about the vaccine protective response for infants born from HIV-infected mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine in vertically HIV-exposed uninfected infants and compared them to those of control infants not exposed to the virus. The quantitative determination of specific neutralizing antibodies against hepatitis B, diphtheria, and tetanus were performed blindly on serum samples. The results showed that 6.7% of the HIV-exposed uninfected individuals were nonresponders to hepatitis B vaccine (anti-HBs titer, <10 mIU/ml), and 64.4% were very good responders (anti-HBs titer, >= 1,000 mIU/ml), whereas only 3.6% of the nonexposed infants were nonresponders (chi(2) = 10.93; 1 df). The HIV-exposed uninfected infants showed protective titers for diphtheria and tetanus but lower geometric mean anti-tetanus titers compared to those of the HIV-unexposed infants. Our data point to the necessity of evaluating vaccine immune responses in these children and reinforced that alterations in lymphocyte numbers and functions reported for newborns from HIV-infected mothers interfere with the vaccine response. (AU)

• Processo FAPESP: 05/02277-3 - Avaliação da imunidade para a vacina BCG e Hepatite B e do estado nutricional de escolares com AIDS sob suplementação alimentar com pré-bióticos
• Beneficiário: Maria Marluce dos Santos Vilela
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/57557-6 - Caracterização e atividade celular natural killer e maturação de células B em lactentes com exposição vertical ao vírus da imunodeficiência humana
• Beneficiário: Beatriz Mariana Abramczuk
• Modalidade de apoio: Bolsas no Brasil - Mestrado