Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impaired Humoral Response to Vaccines among HIV-Exposed Uninfected Infants

Full text
Author(s):
Abramczuk, Beatriz Mariana [1] ; Mazzola, Tais Nitsch [1] ; Franco Moreno, Yara Maria [1] ; Zorzeto, Tatiane Queiroz [1] ; Quintilio, Wagner [2] ; Wolf, Paulo Silva [2] ; Blotta, Maria Heloisa [3] ; Morcillo, Andre Moreno [1] ; Nolasco da Silva, Marcos Tadeu [1] ; dos Santos Vilela, Maria Marluce [1]
Total Authors: 10
Affiliation:
[1] State Univ Campinas Med Sch, Ctr Invest Pediat, Dept Pediat, BR-35218972 Sao Paulo - Brazil
[2] Butantan Inst, Sao Paulo - Brazil
[3] State Univ Campinas Med Sch, Dept Clin Pathol, BR-35218972 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Clinical and Vaccine Immunology; v. 18, n. 9, p. 1406-1409, SEP 2011.
Web of Science Citations: 37
Abstract

Little is known about the vaccine protective response for infants born from HIV-infected mothers. We evaluated the antibody response to hepatitis B, tetanus, and diphtheria vaccine in vertically HIV-exposed uninfected infants and compared them to those of control infants not exposed to the virus. The quantitative determination of specific neutralizing antibodies against hepatitis B, diphtheria, and tetanus were performed blindly on serum samples. The results showed that 6.7% of the HIV-exposed uninfected individuals were nonresponders to hepatitis B vaccine (anti-HBs titer, <10 mIU/ml), and 64.4% were very good responders (anti-HBs titer, >= 1,000 mIU/ml), whereas only 3.6% of the nonexposed infants were nonresponders (chi(2) = 10.93; 1 df). The HIV-exposed uninfected infants showed protective titers for diphtheria and tetanus but lower geometric mean anti-tetanus titers compared to those of the HIV-unexposed infants. Our data point to the necessity of evaluating vaccine immune responses in these children and reinforced that alterations in lymphocyte numbers and functions reported for newborns from HIV-infected mothers interfere with the vaccine response. (AU)

FAPESP's process: 05/02277-3 - Nutritional status and immunity for BCG and Hepatitis B vaccines in children with AIDS under nutritional supplementation with prebiotics
Grantee:Maria Marluce dos Santos Vilela
Support Opportunities: Regular Research Grants