Enhanced mechanical and antimicrobial properties of hydroxypropyl methylcellulose films incorporating silver nanoparticles for wound dressing applications

Autor(es)

Barroso, Bruno Lupi ; Garcia, Arthur Matsudo ; Molina, Celso ; de Vasconcellos, Suzan Pantaroto ; Vital, Vitor Goncalves ; Lago, Joao Henrique Ghilardi ; Camilo, Fernanda Ferraz ; de Oliveira, Larissa Verena Figueiredo

• Tipo de documento: Artigo Científico
• Fonte: POLYMER BULLETIN; v. 81, n. 12, p. 19-pg., 2024-04-12.

Resumo

In this study, we produced hydroxypropyl methylcellulose (HPMC) films containing silver nanoparticles (AgNPs) by a straightforward method for potential wound dressing applications. Polyvinylpyrrolidone (PVP) or polyvinyl alcohol (PVA) was added to these films to improve their mechanical properties. Various compositions of HPMC, PVP/PVA, and AgNPs were tested. The films containing AgNPs exhibited a yellow color, and the confirmation of silver nanoparticles was achieved through UV-Vis analysis. The antimicrobial capacity of HPMC films was assessed against strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Pristine HPMC and HPMC films blended with PVA/PVP displayed no antimicrobial activity, emphasizing the essential role of silver nanoparticles. The films with the highest AgNP content effectively inhibited Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, surpassing the literature data. Some samples showed moderate inhibitory activity against Candida albicans. These films show potential as wound dressings, attributed to their antimicrobial properties and their convenient removal in the shower or by using a gentle water spray which may lead to reduced discomfort compared to traditional dressings. Further research is required to assess their clinical performance. (AU)

• Processo FAPESP: 21/07971-8 - Preparação de análogos de produtos naturais combinados com nanopartículas de prata e sua aplicação contra a bactéria resistente Mycobacterium abscessus
• Beneficiário: Larissa Verena Figueiredo de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/08987-5 - Membranas de celulose como suporte para nanomateriais: preparação e avaliação de propriedades
• Beneficiário: Fernanda Ferraz Camilo
• Modalidade de apoio: Auxílio à Pesquisa - Regular