| Texto completo | |
| Autor(es): Mostrar menos - |
Carvalho, Rafael L.
;
Brito, Tabatta R. P.
;
Amaral, Jonatas B.
;
Monteiro, Fernanda R.
;
Lima, Daniela B.
;
Pereira, Thalles A. M.
;
da Costa, Beatriz F.
;
Furtado, Guilherme E.
;
Rodrigues, Pamella M. M.
;
dos Santos, Carlos A. F.
;
Bachi, Andre L. L.
;
Sarmento, Adriana de Oliveira
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRIENTS; v. 16, n. 15, p. 17-pg., 2024-08-01. |
| Resumo | |
Both cardiometabolic and chronic inflammatory diseases pose a significant challenge to global public health, particularly among older adults. Here, we investigated the interplay between systemic inflammatory status and the cardiometabolic index (CMI) in older men with adequate weight or obesity. In this observational cross-sectional study, older men (71.79 +/- 7.35 years) were separated into groups with normal weight (NW, n = 34) and obesity (O, n = 32) to assess circulating levels of pro- and anti-inflammatory cytokines and CMI. Overall, the O group showed not only a higher inflammatory status but also increased CMI (p < 0.0001) compared with the NW group. Interestingly, only positive correlations were found between pro- and anti-inflammatory cytokines in both groups. Through multivariate regression analysis, IL-6 (beta = -0.2276, p = 0.0003) and IL-10 (beta = 0.2023, p = 0.0030) significantly influenced CMI in the NW group. No significant results were found in the O group. Our findings reinforce the effects of obesity in inflammaging, as well as suggesting that the influence of cytokines in CMI occurs in older men with normal weight, since the elevated pro-inflammatory profile observed in older men with obesity can interfere in this effect. (AU) | |
| Processo FAPESP: | 22/02030-3 - Impacto da soropositividade para Citomegalovírus (CMV) e do perfil da microbiota na resposta imune/inflamatória sistêmica e nas vias aéreas superiores de idosos vacinados para doenças respiratórias |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |