Effect of the Equipment Configuration and Operating Conditions on Process Performance and on Physical Characteristics of the Product During Coating in Spouted Bed

Autor(es)

Publio, M. C. P. ; Oliveira, Wanderley Pereira de ^[2]

• Tipo de documento: Artigo Científico
• Fonte: CANADIAN JOURNAL OF CHEMICAL ENGINEERING; v. 82, n. 1, p. 122-133, Feb. 2004.
• Área do conhecimento: Engenharias - Engenharia Química
• Assunto(s): Indústria farmacêutica

Resumo

The effects of the configuration and operating conditions on the performance of the spouted bed tablet coating process have been studied. The configuration parameters analyzed were the ratio between the draft tube diameter and the inlet orifice diameter, dT/di, and the conical base angle, ã. To analyze the equipment performance the adhesion coefficient, ç, and the increase rate of the tablet mass, K1, were measured as a function of the mass flow rate of the coating material, Ws, of the ratio between the mass feed flow rate of coating suspension relative to mass feed flow rate of the spouting gas, W*s/W*g, of the air flow rate relative to minimum spouting, Q/Qms, and of the feed flow rate of atomising air, Wat. Procedures for the evaluation of the growth kinetics and for measuring the product uniformity are presented. (AU)

• Processo FAPESP: 96/08045-6 - Revestimento de particulas em leito de jorro i.: influencia da configuracao do equipamento e condicoes operacionais nas caracteristicas fisicas do produto obtido.
• Beneficiário: Wanderley Pereira Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular