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Aerobic physical exercise modifies the prostate tumoral environment

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Autor(es):
Veras, Allice Santos Cruz ; Correia, Rafael Ribeiro ; Batista, Victor Rogerio Garcia ; Tavares, Maria Eduarda de Almeida ; Rubira, Rafael Jesus Goncalves ; Fiais, Gabriela Alice ; Giometti, Ines Cristina ; Chaves-Neto, Antonio Hernandes ; Teixeira, Giovana Rampazzo
Número total de Autores: 9
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 332, p. 12-pg., 2023-10-03.
Resumo

Exercise is recognized for its potential role in reducing the risk of certain cancers. However, the molecular mechanisms behind this risk reduction are not fully understood. Here, we hypothesized that aerobic physical exercise induces cancer attenuating effects through the modulation of oxidative stress and inflammation. To test this hypothesis, twenty male Sprague Dawley rats with chemically induced prostate tumors were divided into two groups: Prostate cancer (PC) in the absence and presence of exercise (PC + Ex). Rats in the PC + Ex group performed exercises on a treadmill for 8 weeks, 5 sessions per week, at an intensity of 60 % of maximum capacity. Weight and feed efficiency, Ki-67, apoptosis, prostatic inflammation, and markers of oxidative stress were analyzed. We found that aerobic physical exercise significantly decreased prostate cell proliferation (p < 0.05) across modulation, tumor size, and prostate weight. The PC + Ex group also significantly reduced anti-apoptosis protein expression (p < 0.05) and increased pro-apoptotic protein expression. Furthermore, physical exercise increased enzymatic antioxidant defenses in the prostate, plasma, and whole blood. Moreover, PC + Ex reduced lipid peroxidation and protein carbonyl levels (p < 0.05). In the prostate, there was an increase in antiinflammatory cytokines (IL-10), and a reduction in pro-inflammatory cytokines (IL-6, TNF-alpha, and NF-kappa B) after 8 weeks of physical exercise. In conclusion, we found that aerobic physical exercise is a functional, beneficial, and applicable approach to control PC progression, because it modifies the systemic environment, including the regulation of glucose and circulating lipids. This modification of the cancer cells environment has antiinflammatory and antioxidant effects that attenuate tumor growth. (AU)

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Beneficiário:Allice Santos Cruz Veras
Modalidade de apoio: Bolsas no Brasil - Doutorado
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Modalidade de apoio: Auxílio à Pesquisa - Regular
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Modalidade de apoio: Bolsas no Brasil - Iniciação Científica