On the salient limitations of the methods of assembly theory and their classification of molecular biosignatures

Autor(es)

Uthamacumaran, Abicumaran ; Abrahao, Felipe S. ; Kiani, Narsis A. ; Zenil, Hector

• Tipo de documento: Artigo Científico
• Fonte: NPJ SYSTEMS BIOLOGY AND APPLICATIONS; v. 10, n. 1, p. 5-pg., 2024-08-07.

Resumo

We demonstrate that the assembly pathway method underlying assembly theory (AT) is an encoding scheme widely used by popular statistical compression algorithms. We show that in all cases (synthetic or natural) AT performs similarly to other simple coding schemes and underperforms compared to system-related indexes based upon algorithmic probability that take into account statistical repetitions but also the likelihood of other computable patterns. Our results imply that the assembly index does not offer substantial improvements over existing methods, including traditional statistical ones, and imply that the separation between living and non-living compounds following these methods has been reported before. (AU)

• Processo FAPESP: 23/05593-1 - Dinâmica algorítmica informacional de teorias formais
• Beneficiário: Felipe Sobreira Abrahão
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 21/14501-8 - Sistêmica algorítmica informacional: em direção a uma teoria formal por estruturas parciais mutuamente auto-organizantes
• Beneficiário: Felipe Sobreira Abrahão
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado