Microplastics in the Olfactory Bulb of the Human Brain

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Amato-Lourenco, Luis Fernando ; Dantas, Katia Cristina ; Ribeiro Junior, Gabriel ; Paes, Vitor Ribeiro ; Ando, Romulo Augusto ; Freitas, Raul de Oliveira ; da Costa, Ohanna Maria Menezes M. ; Rabelo, Renata S. ; Bispo, Kelly Cristina Soares ; Carvalho-Oliveira, Regiani ; Mauad, Thais

• Tipo de documento: Artigo Científico
• Fonte: JAMA NETWORK OPEN; v. 7, n. 9, p. 11-pg., 2024-09-16.

Resumo

Importance Microplastic (MP) pollution is an emerging environmental and health concern. While MPs have been detected in various human tissues, their presence in the human brain has not been documented, raising important questions about potential neurotoxic effects and the mechanisms by which MPs might reach brain tissues. Objective To determine the presence of MPs in the human olfactory bulb and to analyze their characteristics such as size, morphology, color, and polymeric composition. Design, Setting, and Participants This case series study used a cross-sectional design involving the analysis of olfactory bulb tissues obtained from deceased individuals during routine coroner autopsies. The sampling procedures were conducted at S & atilde;o Paulo City Death Verification Service, with laboratory analysis carried out at the Brazilian Synchrotron Light Laboratory (LNLS). Participants included 15 adult individuals who had been residents of S & atilde;o Paulo for more than 5 years and underwent coroner autopsies. Exclusion criteria included previous neurosurgical interventions. Data analysis was performed in April 2024. Exposure The primary exposure assessed was the presence of MPs in the olfactory bulb, analyzed through direct tissue examination and digested tissue filtration followed by micro-Fourier transform infrared spectroscopy. Main Outcomes and Measures The main outcomes were the identification and characterization of MPs within the olfactory bulb, including their size, morphology, color, and polymeric composition. Results The median age of the 15 deceased individuals was 69.5 years, ranging from 33 to 100 years, with 12 males and 3 females. MPs were detected in the olfactory bulbs of 8 out of 15 individuals. A total of 16 synthetic polymer particles and fibers were identified, with 75% being particles and 25% being fibers. The most common polymer detected was polypropylene (43.8%). Sizes of MPs ranged from 5.5 mu m to 26.4 mu m for particles, and the mean fiber length was 21.4 mu m. Polymeric materials were absent in procedural blank and negative control filters, indicating minimal contamination risk. Conclusions and Relevance This case series provides evidence of MPs found in the human olfactory bulb, suggesting a potential pathway for the translocation of MPs to the brain. The findings underscore the need for further research on the health implications of MP exposure, particularly concerning neurotoxicity and the potential for MPs to bypass the blood-brain barrier. (AU)

• Processo FAPESP: 21/10724-2 - Avaliação dos efeitos de microplástico secundário no sistema respiratório de camundongos BALBc e em cultura de células de epitélio brônquico humano BEAS-2B
• Beneficiário: Regiani Carvalho de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular