| Texto completo | |
| Autor(es): |
Marques, Natasha Policei
;
Isikawa, Mileni M.
;
Muradova, Zeinaf
;
Morris, Toby
;
Berbeco, Ross
;
Guidelli, Eder J.
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ADVANCED HEALTHCARE MATERIALS; v. 13, n. 20, p. 12-pg., 2024-04-28. |
| Resumo | |
Successful implementation of X-ray-activated photodynamic therapy (X-PDT) is challenging because most photosensitizers (PSs) absorb light in the blue region, but few nanoscintillators produce efficient blue scintillation. Here, efficient blue-emitting SrF2:Eu scintillating nanoparticles (ScNPs) are developed. The optimized synthesis conditions result in cubic nanoparticles with approximate to 32 nm diameter and blue emission at 416 nm. Coating them with the meso-tetra(n-methyl-4-pyridyl) porphyrin (TMPyP) in a core-shell structure (SrF@TMPyP) results in maximum singlet oxygen (1O2) generation upon X-ray irradiation for nanoparticles with 6TMPyP depositions (SrF@6TMPyP). The 1O2 generation is directly proportional to the dose, does not vary in the low-energy X-ray range (48-160 kVp), but is 21% higher when irradiated with low-energy X-rays than irradiations with higher energy gamma rays. In the clonogenic assay, cancer cells treated with SrF@6TMPyP and exposed to X-rays present a significantly reduced survival fraction compared to the controls. The SrF2:Eu ScNPs and their conjugates stand out as tunable nanoplatforms for X-PDT due to the efficient blue emission from the SrF2:Eu cores; the ability to adjust the scintillation emission in terms of color and intensity by controlling the nanoparticle size; the efficient 1O2 production when conjugated to a PS and the efficacy of killing cancer cells. Europium-doped strontium fluoride (SrF2:Eu) scintillating nanoparticles present tunable scintillation color and intensity by varying the nanoparticle size, efficient singlet oxygen production when conjugated to a photosensitizer (PS), and ability to kill cancer cells only when conjugated to the PS and exposed to X-Rays. image (AU) | |
| Processo FAPESP: | 21/00786-0 - Desenvolvimento de nanodispositivos teranósticos com propriedades dosimétricas para aplicações em física médica |
| Beneficiário: | Éder José Guidelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |