Exploring the Therapeutic Potential of Benfotiamine in a Sporadic Alzheimer's-Like Disease Rat Model: Insights into Insulin Signaling and Cognitive function

Autor(es)

Cardinali, Camila A. E. F. ; Martins, Yandara A. ; Moraes, Ruan C. M. ; Costa, Andressa P. ; Alencar, Mayke B. ; Silber, Ariel M. ; Torrao, Andrea S.

• Tipo de documento: Artigo Científico
• Fonte: ACS Chemical Neuroscience; v. 15, n. 16, p. 13-pg., 2024-07-15.

Resumo

Alzheimer's disease (AD) is a complex neurodegenerative process, also considered a metabolic condition due to alterations in glucose metabolism and insulin signaling pathways in the brain, which share similarities with diabetes. This study aimed to investigate the therapeutic effects of benfotiamine (BFT), a vitamin B1 analog, in the early stages of the neurodegenerative process in a sporadic model of Alzheimer's-like disease induced by intracerebroventricular injection of streptozotocin (STZ). Supplementation with 150 mg/kg of BFT for 7 days reversed the cognitive impairment in short- and long-term memories caused by STZ in rodents. We attribute these effects to BFT's ability to modulate glucose transporters type 1 and 3 (GLUT1 and GLUT3) in the hippocampus, inhibit GSK3 activity in the hippocampus, and modulate the insulin signaling in the hippocampus and entorhinal cortex, as well as reduce the activation of apoptotic pathways (BAX) in the hippocampus. Therefore, BFT emerges as a promising and accessible intervention in the initial treatment of conditions similar to AD. (AU)

• Processo FAPESP: 17/10801-1 - Benfotiamina e hormônio tireoideano: influência sobre o metabolismo energético neuronal e a progressão da neurodegeneração em um modelo experimental semelhante à Doença de Alzheimer
• Beneficiário: Andréa da Silva Torrão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/12620-0 - Composição de membrana celular e estresse oxidativo no sistema nervoso durante o envelhecimento e a neurodegeneração
• Beneficiário: Andréa da Silva Torrão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/12938-0 - O metabolismo de aminoácidos em Trypanosoma cruzi: uma caixa de ferramentas para sobreviver em ambientes hostis
• Beneficiário: Ariel Mariano Silber
• Modalidade de apoio: Auxílio à Pesquisa - Temático