| Texto completo | |
| Autor(es): |
e-Lacerda, Rodrigo Rodrigues
;
Barra, Nicole G.
;
Fang, Han
;
Anhe, Gabriel Forato
;
Schertzer, Jonathan D.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ISCIENCE; v. 27, n. 11, p. 17-pg., 2024-11-15. |
| Resumo | |
Obesity is associated with compartmentalized changes in immune responses that can be protective or pathogenic. It has been proposed that obesity-related changes in the microbiota influence allergic lung inflammation. We hypothesized that sensors of the bacterial cell wall influenced allergenic lung inflammation during obesity. Ovalbumin (OVA)-induced lung inflammation was similar in female Nod1-'- and wild- type mice during high-fat-diet-induced obesity, but allergic lung inflammation was higher in obese, high- fat-diet-fed female Nod2-'- mice. Obese Nod2-'- mice had higher inflammatory cell infiltration in the bronchial alveolar lavage (BAL) and lungs, pulmonary fibrosis, mucus levels, hypertrophy and hyperplasia of goblet cells, M2 alveolar macrophage infiltration, interleukin-4 (IL-4), IL-5, IL-6, and lower CXCL1 and IL- 22. Therefore, Nod2 protects against excessive lung inflammation and is a bacterial sensor that relays protective responses to allergenic lung inflammation in obese female mice. (AU) | |
| Processo FAPESP: | 21/09365-8 - Participação de NOD1, NOD2 e Ripk2 na exacerbação da doença alérgica das vias aéreas associada à obesidade |
| Beneficiário: | Rodrigo Rodrigues e Lacerda |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |
| Processo FAPESP: | 19/03751-3 - Influência da história de Obesidade originada em diferentes momentos da vida na inflamação pulmonar alérgica |
| Beneficiário: | Rodrigo Rodrigues e Lacerda |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |