| Texto completo | |
| Autor(es): |
Teixeira, Samantha K.
;
Rossi, Fernando P. N.
;
Patane, Jose L.
;
Neyra, Jennifer M.
;
Jensen, Ana Vitoria V.
;
Horta, Bernardo L.
;
Pereira, Alexandre C.
;
Krieger, Jose E.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 14, n. 1, p. 10-pg., 2024-11-15. |
| Resumo | |
Despite the identification of numerous genetic variants affecting SBP in European populations, their applicability in admixed populations remains unclear. This study evaluates the predictive efficacy of a systolic blood pressure (SBP) polygenic risk score (PRS), derived from the UK Biobank data, in two Brazilian cohorts. We analyzed 944 K genetic variants consistent across an independent UK Biobank dataset, Brazilian cohorts, and HapMap database. Results show a significant association between increased PRS and SBP, as well as hypertension, in each study groups analyzed. An increase of one standard deviation in the PRS showed a significant association with SBP (beta [95% CI] (mmHg) = 5.2 [5.1-5.3], 2.8 [2.1-3.5] and 2.6 [2.2-3.0]) and hypertension (odds ratio (OR) [95% CI] = 1.56 [1.54-1.56], 1.28 [1.2-1.4] and 1.47 [1.3-1.6]) in an independent UKB dataset, Baependi, and Pelotas, respectively. The associations were weaker in the Brazilian samples and the reduced association was noticeable in the Pelotas vs. the UK comparison for hypertension stages 1 and 2 (OR [95% CI] = 2.1 [1.5-3.1] and 3.0 [1.9-4.7] vs. 2.5 [2.2-2.8] and 4.9 [4.4-5.6]), whereas the Baependi data showed no significance for stage 1 hypertension. This trend mirrors findings in homogeneous African and Asian populations with diverse genetic architecture, highlighting the limitations of European-based PRS also in admixed populations. These insights are crucial for developing tailored disease prevention and management strategies in ethnically diverse groups. (AU) | |
| Processo FAPESP: | 13/17368-0 - Genômica Cardiovascular: mechanismos & novas terapias - CVGen mech2ther |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/50216-5 - Caracterizacao da populacao ideal de celulas cardiacas derivadas de hipsc para a regeneracao cardiaca apos infarto do miocardio. (fapesp-astrazeneca) |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE |
| Processo FAPESP: | 14/50889-7 - Inct 2014 - em medicina assistida por computacao cientifica (macc). |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |