Autor(es)

Almeida, Luisa Souza ; Garcia, Rodrigo Henrique dos Santos ; Ticona, Julian ; Cuffini, Silvia L. ; Deazevedo, Eduardo Ribeiro ; Colnago, Luiz Alberto

• Tipo de documento: Artigo Científico
• Fonte: Analytical Chemistry; v. 96, n. 21, p. 8-pg., 2024-05-13.

Resumo

Nuclear magnetic resonance (NMR) longitudinal rotating frame relaxation time (T-1 rho), rarely used in low-field NMR, can be more effective than conventional T-1 and T-2 relaxation times to differentiate polymorphic forms of solid pharmaceuticals. This could be attributed to T-1 rho sensibility to structural and molecular dynamics that can be enhanced by changing the strength of the oscillating magnetic field (B-1) of spinlock pulses. Here, we compared the capacity of T-1, T-2, and T-1 rho to differentiate inactive (A) and active (C) crystalline forms of the World Health Organization essential drug Mebendazole. The results showed that T-1 and T-2 values of both forms were statistically identical at 0.47 T. Conversely, T-1 rho of both forms measured with weak spinlock B-1 fields, ranging from 0.08 to 0.80 mT were statistically different in the same spectrometer. The T-1 rho also has the limit of detection to detect the presence of at least 10% of inactive A form in the active C form. Therefore, T-1 rho, measured with weak spinlock B-1 fields can be an effective, streamlined, and complementary approach for characterizing not only solid active pharmaceutical ingredients but other solid-state materials as well. (AU)

• Processo FAPESP: 21/12694-3 - Aplicações das espectroscopias de RMN e infravermelho na análise não-destrutiva de produtos e processos agroindustriais
• Beneficiário: Luiz Alberto Colnago
• Modalidade de apoio: Auxílio à Pesquisa - Regular