| Texto completo | |
| Autor(es): |
Luyen, Nguyen Dinh
;
Hao, Nguyen Thanh
;
Bastos, Jairo Kenupp
;
Ha, Nguyen Xuan
;
Hung, Nguyen Huy
;
Gioi, Dong Huy
;
Linh, Nguyen Ngoc
;
Son, Ninh The
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 9, n. 23, p. 10-pg., 2024-06-18. |
| Resumo | |
Phytochemical study of green propolis alcohol extract of Brazilian Caatinga Mimosa tenuiflora (Willd.) Poir resulted in the separation of six flavonoids, including quercetin 3-methyl ether (1) and 3,3 '-O-dimethylquercetin (2), and four flavanones eriodictyol 5-O-methyl ether (3), 5,4 '-dihydroxy-6,7-dimethoxyflavanone (4), licoflavanone (5), and macarangaflavanone B (6). All these metabolites were first isolated from green propolis and the genus Mimosa. Metabolites 3-4 also established chemotaxonomic significance since they had never been observed in the bean family Fabaceae. Flavones 1-2 showed strong antioxidative activity against DPPH (1,1-diphenyl-2-picryl hydrazyl) radicals with IC50 values of 12.40 and 16.23 mu g/mL, respectively. All six isolates showed anti-inflammatory effects against NO (nitric oxide) production in LPS (lipopolysaccharide)-stimulated Raw 264.7 cells, in which the activity of flavone 1 was better than the standard dexamethasone (IC50 13.35 mu g/mL). Flavonoids 1-3 also strongly controlled the growth of the Gram-positive bacteria Bacillus subtilis ATCC 6051, and Staphylococcus aureus ATCC 29213 with MIC values of 32-64 mu g/mL. Six isolated flavonoids exhibited strong or moderate mosquito larvicidal activity against Aedes aegypti and Ae. albopictus fourth instar larvae with the 24 h LC50 values of 29.62-55.89 mu g/mL. By in silico approach, compound 1 was a non-toxic agent with an LD50 value of 5000 mg/kg. (AU) | |
| Processo FAPESP: | 21/01411-0 - Estudo químico da própolis da Caatinga produzida por Apis mellifera e reisolamento de compostos da própolis vermelha para realização de ensaios biológicos e desenvolvimento de métodos analíticos |
| Beneficiário: | Ninh The Son |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |