Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study

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Meneghini, Vandrize ; Tebar, William Rodrigues ; Santos, Itamar Souza ; Janovsky, Carolina Castro Porto Silva ; de Almeida-Pititto, Bianca ; Birck, Marina Gabriela ; Lotufo, Paulo Andrade ; Goulart, Alessandra Carvalho ; Sgarbi, Jose Augusto ; Teixeira, Patricia de Fatima dos Santos ; da Silva, Gisela Tunes ; Bensenor, Isabela Martins

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; v. 109, n. 2, p. 13-pg., 2024-01-18.

Resumo

Context The presence of thyroid peroxidase antibodies (TPOAbs) may be considered as an indicator of adverse health outcomes.Objective We aimed to investigate the potential determinants of TPOAb levels and to analyze the association between TPOAb titers and the risk of all- and specific-cause mortality.Methods Baseline and longitudinal data of 13 187 participants from the ELSA-Brasil Study were analyzed. We investigated the association of TPOAb, detectability, positivity, and persistent positivity with sociodemographic and lifestyle factors using logistic regressions. Cox proportional hazards and Fine-Gray subdistribution hazard regression analyses were used to verify the association of TPOAbs with mortality.Results The determinants of TPOAb detectability and positivity were younger age, higher body mass index, female sex, and former and current smoking status. Black, mixed, and other self-reported races, intermediate and higher education, and heavy drinking were determinants of detectable and positive TPOAb levels. Female sex, White race, and former smoking were determinants of persistent TPOAb positivity at 2 visits, although only the female sex maintained its association at 3 visits. Moreover, after multivariate adjustment, there were associations between higher levels of TPOAbs and higher risk of cancer-related mortality among men, and TPOAb detectability and mortality by other causes among women.Conclusion Sociodemographic and lifestyle-related factors were determinants of multiple TPOAb categories. TPOAb levels were associated with mortality risk; however, the low mortality rate in this sample might have compromised this finding. We suggest further studies to explore the clinical importance of detectable TPOAb levels, not only its positivity, as a potential marker of inflammation. (AU)

• Processo FAPESP: 19/23734-6 - Doenças inflamatórias crônicas e mortalidade geral, por doença cardiovascular e outras causas: associação com fatores de risco, Aterosclerose subclínica e eventos cardiovasculares fatais e não fatais no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/04416-3 - Associação de Lúpus, Síndrome de Sjögren, Vasculites, Doença Celíaca e Psoríase com escore de cálcio na linha de base e incidência/progressão de escore de cálcio, mortalidade geral e por doença cardiovascular no seguimento de 8 anos do ELSA-Brasil
• Beneficiário: William Rodrigues Tebar
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/06798-0 - Doença tireoidiana autoimune e doenças inflamatórias: associação com a Aterosclerose subclínica e com mortalidade geral e por doenças cardiovasculares no ELSA-Brasil
• Beneficiário: Vandrize Meneghini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado