Autor(es)

Rodrigues, Isabella Caroline Pereira ; Pereira, Karina Danielle ; Luchessi, Augusto Ducati ; Lopes, Eder Socrates Najar ; Gabriel, Lais Pellizzer

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION; v. N/A, p. 14-pg., 2024-07-27.

Resumo

Bone defects and injuries are common, and better solutions are needed for improved regeneration and osseointegration. Bioresorbable membranes hold great potential in bone tissue engineering due to their high surface area and versatility. In this context, polymers such as poly(lactic-co-glycolic acid) (PLGA) can be combined with osteoconductive materials like hydroxyapatite (HA) nanoparticles (NPs) to create membranes with enhanced bioactivity and bone regeneration. Rotary Jet spinning (RJS) is a powerful technique to produce these composite membranes. This study presents an innovative and efficient method to obtain PLGA-HA(NPs) membranes with continuous fibers containing homogeneous HA(NPs) distribution. The membranes demonstrated stable thermal degradation, allowing HA(NPs) quantification. In addition, the PLGA-HA(NPs) presented osteoconductivity, were not cytotoxic, and had high cell adhesion when cultured with pre-osteoblastic cells. These findings demonstrate the potential of RJS to produce PLGA-HA(NPs) membranes for easy and effective application in bone regeneration. (AU)

• Processo FAPESP: 20/07923-0 - Desenvolvimento de biotintas bioativas e produção de scaffolds bioabsorvíveis customizados por manufatura aditiva e rotofiação para o reparo de tecidos ósseos
• Beneficiário: Laís Pellizzer Gabriel
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/14679-9 - Desenvolvimento de scaffolds farmacológicos e osteocondutivos baseados em Ti6Al4V processados por manufatura aditiva e membranas biorreabsorvíveis por rotofiação
• Beneficiário: Isabella Caroline Pereira Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 23/11076-0 - Biofabricação e Engenharia Tecidual aplicados no desenvolvimento de matrizes tridimensionais osteocondutivas e farmacológicas para a obtenção de implantes ósseos
• Beneficiário: Laís Pellizzer Gabriel
• Modalidade de apoio: Auxílio à Pesquisa - Regular