Autor(es)

Rodrigues, Isabella Caroline Pereira ; Clark, Luis Carlos Orrantia ; Kuang, Xiao ; Flores, Regina Sanchez ; Lopes, Eder Socrates Najar ; Gabriel, Lais Pellizzer ; Zhang, Yu Shrike

• Tipo de documento: Artigo Científico
• Fonte: COMPOSITES PART B-ENGINEERING; v. 275, p. 11-pg., 2024-02-28.

Resumo

Bone tissue engineering strategies face considerable challenges owing to the complexity of the bone. This study introduces an unconventional method based on multimaterial 3D coextrusion-(bio)printing to address some of these challenges. The strategy enables simultaneous (bio)printing of a poly(lactic-co-glycolic acid)-based polymer ink laden with hydroxyapatite and a gelatin methacryloyl (GelMA)-based hydrogel bioink containing mesenchymal stem cells (MSCs). The resulting composite scaffolds exhibited a trabecular bone-like porosity and favorable compressive properties, surpassing those of GelMA alone. The (bio)printed MSCs demonstrated favorable viability, proliferation, morphology, and differentiation. This converged approach in multimaterial (bio)printing has the potential to transform the field of bone tissue engineering, offering a more efficient and effective way to regenerate skeletal tissues. (AU)

• Processo FAPESP: 20/14679-9 - Desenvolvimento de scaffolds farmacológicos e osteocondutivos baseados em Ti6Al4V processados por manufatura aditiva e membranas biorreabsorvíveis por rotofiação
• Beneficiário: Isabella Caroline Pereira Rodrigues
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/07923-0 - Desenvolvimento de biotintas bioativas e produção de scaffolds bioabsorvíveis customizados por manufatura aditiva e rotofiação para o reparo de tecidos ósseos
• Beneficiário: Laís Pellizzer Gabriel
• Modalidade de apoio: Auxílio à Pesquisa - Regular