| Texto completo | |
| Autor(es): |
Squillante, Lucas
;
Mello, Isys F.
;
Ricco, Luciano S.
;
Minicucci, Marcos F.
;
Ukpong, Aniekan Magnus
;
Seridonio, Antonio C.
;
Lagos-Monaco, Roberto E.
;
de Souza, Mariano
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HELIYON; v. 10, n. 15, p. 6-pg., 2024-08-15. |
| Resumo | |
Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Gr & uuml;neisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes. (AU) | |
| Processo FAPESP: | 11/22050-4 - Investigação das propriedades termodinâmicas e de transporte de sistemas eletrônicos fortemente correlacionados |
| Beneficiário: | Valdeci Pereira Mariano de Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |