Immunohistochemical study of stromal and vascular components of tonsillar polyps: high endothelial venules as participants of the polyp's lymphoid tissue

Autor(es)

Barreto, Icleia ^[1] ; Costa, Ana Flavia ^[1] ; Martins, Marilia Trierveiler ^[2] ; Furuse, Cristiane ^[3] ; de Araujo, Vera Cavalcanti ^[3] ; Altemani, Albina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Dept Pathol, Fac Med Sci, BR-13084971 Sao Paulo - Brazil

^[2] Univ Sao Paulo USP, Dept Oral Pathol, Sch Dent, Sao Paulo - Brazil

^[3] Sao Leopoldo Mand Inst & Res Ctr, Dept Oral Pathol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Virchows Archiv; v. 459, n. 1, p. 65-71, JUL 2011.
• Citações Web of Science: 6

Resumo

Tonsillar polyps are nonneoplastic lesions usually composed of variable amounts of lymphoid and vascular and connective tissues. All of them are generally assumed to be hamartomatous proliferations, but the profile of vascular and connective components has yet to be explored. The vascular system of the tonsils is complex and includes highly specialized structures (i.e., high endothelial venules (HEVs)) involved in lymphocyte homing into lymphoid tissues. In 14 tonsillar polyps and 26 control tonsils, an immunohistochemical study was performed using CD34 (blood vessels and HEVs), MECA-79 (HEVs), D2-40 (lymphatic vessels), Ki-67, collagens I and III, fibronectin, and tenascin-C. The polyps showed increased total lymphatic area, whereas the number of blood vessels and lymphatics and the blood vascular area did not differ significantly from those of control tonsils. Rare Ki-67+ endothelial cells were found. In the polyps, we detected, possibly for the first time, HEVs amid lymphoid tissue, and that the amount of the latter correlated positively with HEV density. The polyps also presented lesser amounts of fibronectin and collagens I and III than in normal tonsils, which were distributed in a disorganized fashion. Tenascin-C expression was uncommon in the polyps and control tonsils. Tonsillar polyps are composed of disorganized connective tissue and lymphatic channels which can be considered hamartomatous proliferations. However, the lymphoid component is possibly reactive due to its relationship with the HEVs. The highly differentiated phenotype of the HEVs and their complex biology are not in agreement with what would be expected for a component of hamartomatous nature. (AU)

• Processo FAPESP: 10/51571-0 - Identificação das alterações genéticas e epigenéticas no carcinoma adenóide cístico com transformação para alto grau
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/13759-6 - Polios tonsilares com componentes fibroso, linfoide e linfagiomatoso - estudo histologico e imunoistoquimico.
• Beneficiário: Albina Messias de Almeida Milani Altemani
• Modalidade de apoio: Auxílio à Pesquisa - Regular