Analysis of Liquid Crystalline Nanoparticles by Small Angle X-Ray Diffraction: Evaluation of Drug and Pharmaceutical Additives Influence on the Internal Structure

Autor(es)

Rossetti, Fabia Cristina ^[1] ; Fantini, Marcia C. A. ^[2] ; Carollo, Aline Regina H. ^[1] ; Tedesco, Antonio Claudio ^[3] ; Lopes Badra Bentley, Maria Vitoria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Inst Fis, BR-05508 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Filosofia Ciencias Letras Ribeirao Preto, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pharmaceutical Sciences; v. 100, n. 7, p. 2849-2857, JUL 2011.
• Citações Web of Science: 18

Resumo

The goal of this work was to study the liquid crystalline structure of a nanodispersion delivery system intended to be used in photodynamic therapy after loading with photosensitizers (PSs) and additives such as preservatives and thickening polymers. Polarized light microscopy and light scattering were performed on a standard nanodispersion in order to determine the anisotropy of the liquid crystalline structure and the mean diameter of the nanoparticles, respectively. Small angle X-ray diffraction (SAXRD) was used to verify the influence of drug loading and additives on the liquid crystalline structure of the nanodispersions. The samples, before and after the addition of PSs and additives, were stable over 90 days, as verified by dynamic light scattering. SAXRD revealed that despite the alteration observed in some of the samples analyzed in the presence of photosensitizing drugs and additives, the hexagonal phase still remained in the crystalline phase. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100: 2849-2857, 2011 (AU)

• Processo FAPESP: 04/09465-7 - Laboratório multiusuário de caracterização de sistemas de liberação micro - e nanodispersos de fármacos
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 04/05280-2 - Nanoemulsões como sistema de liberação cutânea para a zinco ftalocianina tetrassulfonada na terapia fotodinâmica do câncer de pele: obtenção, caracterização e estudos in vitro de liberação e permeação/penetração cutânea
• Beneficiário: Fábia Cristina Rossetti
• Modalidade de apoio: Bolsas no Brasil - Mestrado