Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson's disease

Autor(es)

Neto, Arnaldo Fim ; Godinho, Fabio ; da Silva, Luiz Ricardo Trajano ; de Luccas, Julia Baldi ; Takahata, Andre Kazuo ; Figueiredo, Eberval Gadelha ; Carlotti Junior, Carlos Gilberto ; Rocha, Maria Sheila Guimaraes ; Soriano, Diogo Coutinho

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NEUROPHYSIOLOGY; v. 171, p. 10-pg., 2025-01-29.

Resumo

Introduction: Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson's disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP). Methods: The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG). Results: FOG patients presented enhanced alpha bandpower (FOG vs. n-FOG: 0.331 f 0.087 vs. 0.248 f 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG vs. n-FOG: 0.610 f 0.068 vs. 0.524 f 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = -0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index. Conclusion: These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms. Significance: The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment. (AU)

• Processo FAPESP: 18/14285-0 - Diferenças espectrais dos potenciais de campo local registrados em núcleos subtalâmicos bilaterais de pacientes com Doença de Parkinson
• Beneficiário: Julia Baldi de Luccas
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 22/03243-0 - Pesquisa interdisciplinar de técnicas de aprendizado de máquina e inteligência artificial para desenvolvimento de tecnologias de processamento de sinais, imagens e linguagem natural
• Beneficiário: André Kazuo Takahata
• Modalidade de apoio: Auxílio à Pesquisa - Projeto Inicial