| Texto completo | |
| Autor(es): |
Cruz, Andressa Tardim
;
Di Filippo, Leonardo Delello
;
Duarte, Jonatas Lobato
;
Guillot, Antonio Jose
;
Perez-Garcia, Alberto
;
Melero, Ana
;
Chorilli, Marlus
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | COSMETICS; v. 12, n. 1, p. 10-pg., 2025-02-01. |
| Resumo | |
Trans-resveratrol (RES) is a natural polyphenol known for its antioxidant, anti-inflammatory, and anti-aging properties, making it highly valuable in cosmetic applications. Solid lipid nanoparticles (SLNs) offer a promising solution to enhance RES's stability and cutaneous availability. This study aimed to develop and characterize SLNs encapsulating RES for enhanced skin delivery. Multiple methodologies were evaluated to determine the impact of preparation methods on formulation stability. SLNs were formulated using stearic acid, soy phosphatidylcholine, polysorbate 80, cetyltrimethylammonium bromide, and poloxamer 407, with variations in heating temperatures and homogenization techniques. Stability assessments were conducted over 90 days, examining organoleptic properties of the hydrodynamic diameter, polydispersity index, and zeta potential. Encapsulation efficiency and skin permeation studies were performed to investigate the efficacy of SLNs in delivering RES. Results demonstrated that formulations prepared with Ultra Turrax at 24,000 rpm and heating at higher temperatures exhibited enhanced stability and smaller particle sizes. The selected formulations, F1 (prepared at 80 degrees C) and F2 (prepared at 70 degrees C) presented encapsulation efficiencies of 70% and 72%, respectively. Skin permeation studies confirmed the ability of SLNs to facilitate RES delivery through the skin. The study concludes that SLNs are suitable carriers for RES skin delivery, offering improved stability and sustained release, thus representing a promising approach for topical applications to leverage RES's cutaneous therapeutic benefits. (AU) | |
| Processo FAPESP: | 17/05566-3 - Nanopartículas lipídicas sólidas para a incorporação de trans-resveratrol: desenvolvimento, caracterização físico-química, estudo de estabilidade e liberação in vitro. |
| Beneficiário: | Andressa Tardim Cruz |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 12/19568-4 - Avaliação do potencial de sistemas lipídicos nanoestruturados para administração cutânea de trans-resveratrol |
| Beneficiário: | Marlus Chorilli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/24365-9 - Estudo de permeação cutânea in vitro do trans-resveratrol incorporado em nanoparticulas lipídicas sólidas |
| Beneficiário: | Andressa Tardim Cruz |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica |