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Paris Junior, Jose Alberto ; Nogueira, Leonardo Gorla ; Cerqueira, Igor Henrique ; Catirse, Nicole Pichirilli ; da Silva, Lucas Henrique Domingos ; Fernandes, Paula de Abreu ; Colturato, Vitoria Maria Medalha ; Dias, Diogenes dos Santos ; Ribeiro, Clovis Augusto ; Dametto, Alessandra Cristina ; Silva, Jhonatan Miguel ; Barud, Hernane da Silva ; Resende, Flavia Aparecida

• Tipo de documento: Artigo Científico
• Fonte: WASTE AND BIOMASS VALORIZATION; v. N/A, p. 15-pg., 2024-10-10.

Resumo

Fruit and vegetable waste is a promising source to produce functional polymeric films, given the urgent need to replace petroleum-based polymeric materials due to their environmental impacts and limited sustainability. In the present study, we produced an antimicrobial surface film derived from watermelon mesocarp containing chlorhexidine in digluconate form (W-CHX) with applicability for coating 2D surfaces and medical devices. The films were obtained by hydrothermal steps and casting, and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermal stability profile, water barrier properties, fluid handling ability, and drug release, in addition to the assessment of antibacterial, cytotoxic, and mutagenic potential. Although the W-CHC films have demonstrated promising mechanical and antibacterial properties against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, their cytotoxicity and genotoxicity in keratinocytes (HaCaT cells) as revealed by the Comet assay highlight the need for cautious use for topical applications. Therefore, the attributes exhibited by W-CHX films offer a pathway to address the escalating need for biopolymer-based materials with enhanced performance, particularly in extracorporeal applications necessitating microbial growth inhibition. Graphical AbstractAntimicrobial surface film: watermelon mesocarp-only biopolymers with chlorhexidine (CHX) (AU)

• Processo FAPESP: 19/25318-0 - EMU concedido no processo 2017/18782-6: Microscópio Leica DM4
• Beneficiário: Eliane Trovatti
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 17/16278-9 - Estudo do potencial genotoxicológico e da permeabilidade em células Caco-2 de complexos metálicos com promissoras atividades biológicas
• Beneficiário: Flávia Aparecida Resende Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs