| Texto completo | |
| Autor(es): Mostrar menos - |
Voltarelli, Vanessa Azevedo
;
Amano, Mariane Tami
;
Tobias, Gabriel Cardial
;
Borges, Gabriela Silva
;
da Paixao, Ailma Oliveira
;
Pereira, Marcelo Gomes
;
Camara, Niels Olsen Saraiva
;
Caldeira, Waldir
;
Ribeiro, Alberto Freitas
;
Otterbein, Leo Edmond
;
Negrao, Carlos Eduardo
;
Turner, James Edward
;
Brum, Patricia Chakur
;
Camargo, Anamaria Aranha
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ISCIENCE; v. 27, n. 6, p. 16-pg., 2024-06-08. |
| Resumo | |
Aerobic exercise training (AET) has emerged as a strategy to reduce cancer mortality, however, the mechanisms explaining AET on tumor development remain unclear. Tumors escape immune detection by generating immunosuppressive microenvironments and impaired T cell function, which is associated with T cell mitochondrial loss. AET improves mitochondrial content and function, thus we tested whether AET would modulate mitochondrial metabolism in tumor -infiltrating lymphocytes (TIL). Balb/c mice were subjected to a treadmill AET protocol prior to CT26 colon carcinoma cells injection and until tumor harvest. Tissue hypoxia, TIL infiltration and effector function, and mitochondrial content, morphology and function were evaluated. AET reduced tumor growth, improved survival, and decreased tumor hypoxia. An increased CD8 + TIL infiltration, IFN- g and ATP production promoted by AET was correlated with reduced mitochondrial loss in these cells. Collectively, AET decreases tumor growth partially by increasing CD8 + TIL effector function through an improvement in their mitochondrial content and function. (AU) | |
| Processo FAPESP: | 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento |
| Beneficiário: | Carlos Eduardo Negrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/13133-0 - Papel relativo da atividade física sobre a densidade e bioenergética mitocondriais de linfócitos T infiltrantes do microambiente tumoral |
| Beneficiário: | Vanessa Azevedo Voltarelli |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |