Aerobic training increases renal antioxidant defence and reduces angiotensin II levels, mitigating the high mortality in SHR-STZ model

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Guzzoni, Vinicius ; de Abreu, Isabel Cristina Mallosto Emerich ; Bertagnolli, Mariane ; Mendes, Roberta Hack ; Bello-Klein, Adriane ; Casarini, Dulce Elena ; Flues, Karin ; Candido, Georgia Orsi ; Paulini, Janaina ; De Angelis, Katia ; Marcondes, Fernanda Klein ; Irigoyen, Maria Claudia ; Sousa Cunha, Tatiana

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY; v. 130, n. 6, p. 13-pg., 2024-07-17.

Resumo

ObjectveThe purpose of the research was to investigate the effects of aerobic training on renal function, oxidative stress, intrarenal renin-angiotensin system, and mortality of hypertensive and diabetic (SHR-STZ) rats.Materials and MethodsBlood pressure, creatinine, urea levels, urinary glucose, urine volume, and protein excretion were reduced in trained SHR-STZ rats.ResultsAerobic training not only attenuated oxidative stress but also elevated the activity of antioxidant enzymes in the kid ' ney of SHR-STZ rats. Training increased intrarenal levels of angiotensin-converting enzymes (ACE and ACE2) as well as the neprilysin (NEP) activity, along with decreased intrarenal angiotensin II (Ang II) levels. Aerobic training significantly improved the survival of STZ-SHR rats.ConclusionThe protective role of aerobic training was associated with improvements in the renal antioxidative capacity, reduced urinary protein excretion along with reduced intrarenal Ang II and increased NEP activity. These findings might reflect a better survival under the combined pathological conditions, hypertension, and diabetes. (AU)

• Processo FAPESP: 10/51904-9 - Sistema renina angiotensina e calicreina cininas na hipertensão, obesidade, diabetes, desnutrição e sepses: mecanismos moleculares, celulares e fisiopatológicos
• Beneficiário: Dulce Elena Casarini
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/06090-8 - Papel do treinamento físico aeróbio sobre a hipertrofia cardíaca induzida pelo estresse crônico: participação do sistema renina angiotensina e das vias de sinalização JNK e p38 MAPK
• Beneficiário: Vinicius Guzzoni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado